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In all cases, a rapid fall in the plasma paracetamol concentration was observed; the total amounts of drug removed varied from 364.

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Denmark and Norway each had only one propoxyphene death among drug addicts, confirming previous reports of the success of restrictive measures that were introduced in these countries.

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The editor-in-chief of the New England Journal of Medicine accused three of the largest drug companies of "making a mockery" of efforts to create transparency in clinical trials, saying that could lead some important medical publications to avoid publishing their studies.

Competing interests: KH and SS were temporary advisors to the MHRA for its evaluation of the efficacy and safety profile of co-proxamol.

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