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These are three multicenter, randomized, double-blind, parallel group trials comparing Bicalutamide Tablets, USP 150 mg daily monotherapy (adjuvant to previous therapy or under watchful waiting) with placebo, for death or time to disease progression, in a population of 8113 patients with localized or locally advanced prostate cancer.

Licorice may also reduce testosterone levels, which can contribute to hirsutism in women.

Secondary end points included the time until the initiation of cytotoxic chemotherapy, the time until the first skeletal-related event, the best overall soft-tissue response, the time until PSA progression, and a decline in the PSA level of 50% or more from baseline.

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Details of adverse events occurring during the trial were elicited by open questioning.

Examples of first generation antiandrogens include bicalutamide, flutamide, and nilutamide, which inhibit androgen action by binding to the androgen receptor in a competitive fashion, ie, as an antagonist.

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For men considering external beam radiotherapy, the pretreatment evaluation commonly includes, at minimum, a DRE, serum PSA level, and biopsy with Gleason histologic scoring, preferably recording the number of positive cores, the number of cores sampled, and the presence or absence of perineural invasion or tertiary grade.

Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer.

In most trials, both patient and provider know exactly what treatment is being given.

Another way to assess the aggressiveness of the cancer is a gene expression test that can indicate if the cancer has worrisome biological characteristics and if surveillance is safe.

Despite a stage migration towards localized disease, many patients still present with locally advanced or metastatic prostate cancer.

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And a study comparing the outcomes of 393 men who received different doses of external beam radiation therapy for prostate cancer, published in the Journal of the American Medical Association, found that 19.

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In the United States, it is estimated that more than 1 man in 7 will be diagnosed with prostate cancer during his lifetime.

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Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.

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Bicalutamide (Casodex) is a drug prescribed for the treatment of late stage prostate cancer.

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Recently, it has been reported that androgen treatment can induce these fusion events.

Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.

Jason Farrow holds a Bachelor's Degree in Science and is a 4 th year medical student at the University of California, Davis.

Current and future pharmacologic agents used for androgen ablation should target these levels achieved by surgical orchiectomy to optimize the prostate cancer disease-specific outcomes.

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In Step B, from the aspect of operability, a base is preferably added in advance to a 4-fluorothiophenol solution in a suitable reaction solvent (more preferably dropwise addition of a solution containing a base), and compound (2) is added to the mixture (more preferably dropwise addition of a solution containing compound (2)).

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The IHC methods on study used the same commercially available antibody from the preclinical studies that informed the design of our trial.

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An estrogen-like drug called Diethylstilbestrol (DES) was formerly used in hormone blockade, but the side effects were found to be too dangerous.

Hormone therapy can also reduce the amount of semen produced.

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Although DES is effective at reducing testicular production of testosterone, there are concerns over its safety (increased risk of cardiovascular and thrombotic events).

The exception is men who've received androgen deprivation therapy for prostate cancer.

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Other doctors say to wait, because waiting delays the bothersome and serious side effects of hormone therapy.

In the overall EPC analysis, there was a trend towards an improvement in overall survival in patients with locally advanced disease who would otherwise have undergone watchful waiting; however, this was not seen within Trial 24 itself.

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Because LHRH is sometimes called GnRH, or gonadotropin-releasing hormone, these medications are sometimes referred to as GnRH agonists.

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Neoadjuvant EMP resulted in a significant decrease in positive surgical margins in patients with T2b disease in a randomized trial.

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Hepatitis or marked increases in liver enzymes leading to drug discontinuation occurred in approximately 1% of bicalutamide patients in controlled clinical trials.

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Treatment with Casodex should be started at the same time as treatment with an LHRH analog.

For instance, flutamide can cause diarrhea and liver dysfunction while nilutamide can cause interstitial pneumonia.

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Because less than 5% of the patients were at risk when the estimated medians were reached, the hazard ratio, which analyzes the differences in outcome across the entire follow-up period, is a more accurate characterization of the survival benefit and other late-occurring end points than is the estimate of the median time until the event.

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All AEs were mild, and no subjects discontinued the study because of AEs.

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