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My panic disorder with agoraphobia started when I was 16. Clomipramine (Anafranil) is the only thing that controls it. I am now nearly 60 and still take a small dose 25mgs per night. I have tried repeatedly to manage without Clomipramine and to begin with it is fine but then eventually the panic attacks recur and are very debilitating. Thanks to this I have been able to lead a fulfilled life - working both at home and abroad, travelling, driving and looking after children and husband. It frees me up to be myself. I have tried cognitive therapy and other things but always come back to this. It is not nice to be on a high dose though as it affects sexual response. This is why it does not get 10 out of 10.
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From reading the medical literature this is probably the most efective treatment for obsessive compulsive disorder but the side effects led me to change, after a year of use, to a less taxing medication. The weight gain was too much and it made me more confrontational with others. But for bringing my initial problem down to a manageable level before switching, Anafrinil was a life saver.

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