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Activation of the renin-angiotensin axis produces the biologically active peptide angiotensin II, which has several structural and hemodynamic effects, including stimulation of the sympathetic nervous system, vasoconstriction, increased aldosterone release and sodium retention, cardiac remodeling, smooth muscle cells growth and proliferation, vascular inflammation, generation of reactive oxygen species, endothelial dysfunction, renal fibrosis and so forth.

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The use of insulin increased more in the standard-control group than in the intensive-control group, whereas the use of sulfonylureas, including modified-release gliclazide, decreased in both groups over time.

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Angiotensin converting enzyme (ACE) inhibitor plus diuretic combination therapy improves blood pressure control, counterbalances renin-angiotensin system activation due to diuretic therapy and reduces the risk of electrolyte alterations, obtaining at the same time synergistic antiproteinuric effects.

Blood pressure (BP) control in patients with chronic kidney disease is one of the most pressing problems in modern cardiology and nephrology.

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If prolonged hypotension occurs (systolic blood pressure less than 90 mmHg for more than 1 hour) therapy should be withdrawn.

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Aliskiren: May enhance the hyperkalemic effect of ACE Inhibitors.

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If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately.

PCV, and was discontinued untimely less in many cases (0 versus 37 %) (Brandes et al.

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There is less evidence for lipid-lowering and aspirin therapy, although the benefits of these interventions for primary and secondary prevention are likely to apply to older adults whose life expectancies equal or exceed the time frames seen in clinical trials.

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The recommended initial daily dosage of perindopril for the elderly is 4 mg daily, given in one or two divided doses.

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Each of these drug classes has been shown to be effective in the treatment of congestive heart failure, proteinuric chronic kidney disease (diabetic or not) and high-CV risk patients.

Atlantic Diabetes in Pregnancy (DIP): the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria.

It is widely recognized that combination therapy is required to achieve current BP treatment targets.

People with high blood pressure especially need to lower the amount of sodium in their diet.

Impact of self monitoring of blood glucose in the management of patients with non-insulin treated diabetes: open parallel group randomised trial.

Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology; ESC Committee for Practice Guidelines (CPG).

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ALLHAT patients were receiving an antihypertensive drug, a diuretic in most cases, at the time of randomization, when they abruptly abandoned the previous agents and were fully switched to trials drugs.

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Data: One study demonstrated successful pregnancy outcomes (ie, live, healthy infant without severe disability at 2 y after delivery) in 87.

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In the case of lack of BP control, bendroflumethiazide was added to atenolol and perindopril to amlodipine.

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It was recommended that patients with uncontrolled hypertension received antihypertensive therapy with agents other than ACE inhibitors prior to the study.

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In the present study, we compared the effects of a centrally active ACE inhibitor, perindopril, with those of non-centrally active ACE inhibitors, imidapril and enalapril, on cognitive performance in amyloid beta(Abeta) (25-35)-injected mice, a rodent model of Alzheimer's disease.

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