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Catalogue of drugs marketed in Germany in the year 2002, entries 07 079 and 07 080 (Allergodil, nasal spray (solution)), and 72 025 (Nasonex, nasal spray (suspension)), 3 pages.

Influence of the anti-allergic agent, azelastine, on tumor necrosis factor-alpha (TNF-α) secretion from cultured mouse mast cells.

Astelin may cause harm if it is swallowed.

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Meta-analysis of azelastine nasal spray for the treatment of allergic rhinitis.

The histamine is what dilates the blood vessels in your nose and sinuses to cause swelling, redness and itching.

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Whilst some agencies, such as the Food and Drug Administration (FDA), do not require measuring systemic effects when pharmacokinetic measurements are feasible, the European Medicines Agency requires measurement of heart rate and serum potassium, and some require serial electrocardiograms when bioequivalence is not established by pharmacokinetic (PK) studies.

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Azelastine is indicated for the treatment of the symptoms of seasonal allergic rhinitis such as rhinorrhea, sneezing, and nasal pruritus in adults and children 12 years and older.

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Similarly, in PR patients, azelastine nasal spray significantly improved sleeping, reduced daytime somnolence and nasal congestion compared with placebo ().

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If this pattern continues, a patient has a good chance of becoming trapped in a vicious cycle of overuse and dependence that can last for months or years.

In cases of severe nasal obstruction, a short course of oral steroids or topical decongestants, which both should not be given longer than ten days, is recommended.

This dosage form is marketed as Transtec in most European countries by Grunenthal (Napp Pharmaceuticals in the UK, Norpharma in Denmark) for the treatment of moderate to severe and severe non-cancer pain not responding to non-opioids.

This medicine is for seasonal allergies in adults and children who are at least 2 years old, and for year-round allergies in adults and children as young as 6 months old.

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Pre túto skupinu je charakteristický značný anticholínergný účinok (vrátane sedácie) ale výskyt gastrointestinálnych vedľajších účinkov je pomerne nízky.

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Unlike some of the earlier antihistamines, topical application of azelastine produces very low plasma concentrations of the drug which reduces the sedative potential.

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Because azelastine starts working within 15 minutes of application investigators wondered how effective an as-needed regimen would be in controlling the symptoms of rhinitis ().

Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis".

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Patients should be instructed to prime the delivery system before initial use and after storage for 3 or more days (see PATIENT INSTRUCTIONS FOR USE).

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The worse thing you can do is spray the mist onto your septum (the central divide between the nostrils) as this can be the cause of irritation and unwanted side-effects.

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Illustrated patient instructions for proper use accompany each package of azelastine.

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The objective of the study was to determine if greater efficacy could be achieved with the intranasal antihistamine azelastine and the intranasal corticosteroid fluticasone propionate used concurrently compared with the efficacy of each agent alone.

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In a double-blind, randomized, 4-period crossover study, single oral doses of azelastine hydrochloride tablets (A-05610, Allergodil, Radethazin, Azeptin, CAS 79307-93-0) were ingested by 12 healthy volunteers (6 males, 6 females, mean age 25.

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Safety and efficacy of azelastine nasal spray (Astelin NS) for seasonal allergic rhinitis.

However, to date no studies have been designed to assess specifically the effects of azelastine nasal spray on the CNS in humans.

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