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Darifenacin, a selective muscarinic M3 antagonist.

Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients.

The Beers Criteria (see ) lists potentially inappropriate drugs for the elderly by drug class; other similar lists are available.

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Patient characteristics, such as age, race, comorbid conditions, or baseline UI, did not affect the outcomes of the various pharmacologic medications.

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Chapple CR, Arano P, Bosch JL et al: Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase 2 dose-finding study.

Chronic Obstructive Respiratory Disease (COPD) has now been identified as a multi-component disease with airway structural changes, mucociliary dysfunction, and airway inflammation with systemic effects in addition to airflow limitation, which suggests the need for a multi-targeted treatment approach.

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Treatment satisfaction and goal attainment with onabotulinumtoxinA in patients with incontinence due to idiopathic OAB.

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Reasons for this benefit are not clear, but experts have some theories.

There are substantial risks to these procedures, however, including the likely need for long-term intermittent self-catheterization and the risk of malignancy.

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