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Irbesartan was generally well tolerated in the INCLUSIVE study; the most common drug related adverse event was dizziness, which occurred in three percent of patients.

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Metabolic and Endocrine: Weight change, peripheral edema, abnormal lactation, gynecomastia, menstrual irregularities, false results on pregnancy tests, impotency in men and increased libido in women have all been known to occur in some patients on phenothiazine therapy.

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Results of the Reduction of Endpoints in NIDDM (non-insulin-dependent diabetes mellitus) with the Angiotensin II Antagonist Losartan study (15) and the Irbesartan Diabetic Nephropathy Trial (16) showed that ARBs slow the progression of diabetic nephropathy significantly in patients with type 2 diabetes.

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Fonseca FA, Ihara SS, Izar MC, Silva EP, Kasinski N, Lopes IE, Pinto LE, Paiva TB, Tufik S, de Paola AA, Carvalho AC: Hydrochlorothiazide abolishes the anti-atherosclerotic effect of quinapril.

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